Panama Canal

Cross from the Atlantic to the Pacific through one of the great feats of engineering. A Panama Canal cruise combines a bucket-list transit with Caribbean and Central American ports.

The Panama Canal is a 51-mile waterway in Panama that connects the Pacific Ocean with the Caribbean Sea, making it an excellent destination for all sorts of unique cruises. Panama Canal cruises are very unique when compared to other cross-country expeditions, being confined to the waterway itself. You might end up taking a full-length cruise of the entire canal or hitting a few core stops along the way. Either way, you can trust that you’ll be put in front of some truly unique natural beauty and cultural touchpoints. Many different lines offer Panama Canal cruises, meaning you have plenty of options for experiencing the one-of-a-kind passageway. Check out our itineraries below to see how you can experience the Panama Canal – remember to take plenty of holiday as these are generally slightly longer voyages.

Ports

Panama Canal

We found

152 cruises

Crown Princess, Panama Canal
1 / 20
5 % off — 2 days left
Princess Cruises
Duration
16 nights
Date
3 Dec 2026
Ship
Crown Princess
  • Departure - Los Angeles, USA
  • 9 stops  
  • Arrival - Fort Lauderdale, Florida
£1057
From
£1005
Price per person / inside stateroom
Available promotion:
All-In: Upgrade to 'Princess Plus' for £53pp/pd
Norwegian Star, Panama Canal
1 / 15
Discount — 2 days left
Norwegian Cruise Line
Duration
16 nights
Date
4 Dec 2026
Ship
Norwegian Star
  • Departure - Miami, Florida, USA
  • 10 stops  
  • Arrival - San Diego, USA
£2245
From
£2156
Price per person / balcony stateroom
Available promotion:
Upgrade to "Free At Sea" from £99
Island Princess, Panama Canal
1 / 14
5 % off — 2 days left
Princess Cruises
Duration
16 nights
Date
12 Dec 2026
Ship
Island Princess
  • Departure - Fort Lauderdale, Florida
  • 9 stops  
  • Arrival - Los Angeles, USA
£954
From
£907
Price per person / oceanview stateroom
Available promotion:
All-In: Upgrade to 'Princess Plus' for £53pp/pd
Azamara Quest, Panama Canal
1 / 14
5 % off — 2 days left
Azamara
Duration
18 nights
Date
18 Dec 2026
Ship
Azamara Quest
  • Departure - Miami, Florida, USA
  • 9 stops  
  • Arrival - San Francisco, USA
£3529
From
£3353
Price per person / oceanview stateroom
Available promotion:
up to $750 Onboard Credit
Insignia, Panama Canal
1 / 12
5 % off — 2 days left
Oceania Cruises
Duration
15 nights
Date
19 Dec 2026
Ship
Insignia
  • Departure - Miami, Florida, USA
  • 11 stops  
  • Arrival - Callao (Lima), Peru
£3289
From
£3125
Price per person / inside stateroom
Available promotion:
Your World Included™ - Choice of Complimentary Wine & Beer or Shore Excursion Credit
Island Princess, Panama Canal
1 / 14
5 % off — 2 days left
Princess Cruises
Duration
16 nights
Date
28 Dec 2026
Ship
Island Princess
  • Departure - Los Angeles, USA
  • 9 stops  
  • Arrival - Fort Lauderdale, Florida
£1499
From
£1425
Price per person / oceanview stateroom
Available promotion:
All-In: Upgrade to 'Princess Plus' for £53pp/pd
Seven Seas Grandeur, Panama Canal
1 / 9
5 % off — 2 days left
Regent Seven Seas Cruises
Duration
16 nights
Date
29 Dec 2026
Ship
Seven Seas Grandeur
  • Departure - Miami, Florida, USA
  • 9 stops  
  • Arrival - Los Angeles, USA
£11339
From
£10773
Price per person / suite
Coral Princess, Panama Canal
1 / 14
5 % off — 2 days left
Princess Cruises
Duration
23 nights
Date
6 Jan 2027
Ship
Coral Princess
  • Departure - Fort Lauderdale, Florida
  • 12 stops  
  • Arrival - Honolulu (Oahu), Hawaii
£7617
From
£7237
Price per person / suite
Available promotion:
All-In: Upgrade to 'Princess Plus' for £53pp/pd
Queen Victoria, Panama Canal
1 / 26
5 % off — 2 days left
Cunard
Duration
26 nights
Date
10 Jan 2027
Ship
Queen Victoria
  • Departure - Southampton, Great Britain
  • 9 stops  
  • Arrival - Los Angeles, USA
£2299
From
£2185
Price per person / inside stateroom
3 Available promotions:
30% off Signature Packages, Get up to $800 Onboard Credit, Save 10% off your Drinks Package
Seven Seas Splendor, Panama Canal
1 / 9
5 % off — 2 days left
Regent Seven Seas Cruises
Duration
14 nights
Date
12 Jan 2027
Ship
Seven Seas Splendor
  • Departure - Miami, Florida, USA
  • 11 stops  
  • Arrival - Panama City, Panama
£12089
From
£11485
Price per person / suite
10 of 152 pcs