The Panama Canal is a 51-mile waterway in Panama that connects the Pacific Ocean with the Caribbean Sea, making it an excellent destination for all sorts of unique cruises. Panama Canal cruises are very unique when compared to other cross-country expeditions, being confined to the waterway itself. You might end up taking a full-length cruise of the entire canal or hitting a few core stops along the way. Either way, you can trust that you’ll be put in front of some truly unique natural beauty and cultural touchpoints. Many different lines offer Panama Canal cruises, meaning you have plenty of options for experiencing the one-of-a-kind passageway. Check out our itineraries below to see how you can experience the Panama Canal – remember to take plenty of holiday as these are generally slightly longer voyages.
Panama Canal
Cross from the Atlantic to the Pacific through one of the great feats of engineering. A Panama Canal cruise combines a bucket-list transit with Caribbean and Central American ports.
Ports
Panama Canal
We found
151 cruises
1 / 20
5 % off — 2 days left
Duration
16 nights
Date
3 Dec 2026
Ship
Crown Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
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1 / 14
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Duration
16 nights
Date
12 Dec 2026
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
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1 / 14
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Duration
18 nights
Date
18 Dec 2026
Ship
Azamara Quest
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - San Francisco, USA
Available promotion:
up to $750 Onboard Credit
1 / 12
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Duration
15 nights
Date
19 Dec 2026
Ship
Insignia
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Callao (Lima), Peru
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1 / 14
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Duration
16 nights
Date
28 Dec 2026
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
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1 / 9
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Duration
16 nights
Date
29 Dec 2026
Ship
Seven Seas Grandeur
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Los Angeles, USA
1 / 14
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Duration
23 nights
Date
6 Jan 2027
Ship
Coral Princess
- Departure - Fort Lauderdale, Florida
- 12 stops
- Arrival - Honolulu (Oahu), Hawaii
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1 / 26
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Duration
26 nights
Date
10 Jan 2027
Ship
Queen Victoria
- Departure - Southampton, Great Britain
- 9 stops
- Arrival - Los Angeles, USA
3 Available promotions:
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1 / 9
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Duration
14 nights
Date
12 Jan 2027
Ship
Seven Seas Splendor
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Panama City, Panama
1 / 9
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Duration
42 nights
Date
12 Jan 2027
Ship
Seven Seas Splendor
- Departure - Miami, Florida, USA
- 25 stops
- Arrival - Papeete (Tahiti), French Polynesia
1 / 14
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Duration
16 nights
Date
13 Jan 2027
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - San Diego, USA
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1 / 35
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Duration
56 nights
Date
22 Jan 2027
Ship
Queen Anne
- Departure - Fort Lauderdale, Florida
- 30 stops
- Arrival - Fort Lauderdale, Florida
3 Available promotions:
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1 / 35
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Duration
56 nights
Date
22 Jan 2027
Ship
Queen Anne
- Departure - Fort Lauderdale, Florida
- 30 stops
- Arrival - Fort Lauderdale, Florida
3 Available promotions:
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1 / 9
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Duration
16 nights
Date
24 Jan 2027
Ship
Seven Seas Grandeur
- Departure - Los Angeles, USA
- 8 stops
- Arrival - Miami, Florida, USA
1 / 14
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Duration
16 nights
Date
29 Jan 2027
Ship
Island Princess
- Departure - San Diego, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
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1 / 15
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Duration
16 nights
Date
13 Feb 2027
Ship
Norwegian Star
- Departure - San Diego, USA
- 10 stops
- Arrival - Miami, Florida, USA
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1 / 14
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Duration
16 nights
Date
14 Feb 2027
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
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1 / 18
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Duration
20 nights
Date
19 Feb 2027
Ship
Allura
- Departure - San Juan, Puerto Rico
- 15 stops
- Arrival - Miami, Florida, USA
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1 / 17
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Duration
11 nights
Date
22 Feb 2027
Ship
Seven Seas Prestige
- Departure - Panama City, Panama
- 9 stops
- Arrival - Miami, Florida, USA
1 / 9
5 % off — 2 days left
Duration
14 nights
Date
23 Feb 2027
Ship
Seven Seas Grandeur
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Panama City, Panama
1 / 18
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Duration
12 nights
Date
27 Feb 2027
Ship
Allura
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Miami, Florida, USA
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1 / 35
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Duration
19 nights
Date
28 Feb 2027
Ship
Queen Anne
- Departure - Valparaiso, Chile
- 11 stops
- Arrival - Fort Lauderdale, Florida
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1 / 35
5 % off — 2 days left
Duration
19 nights
Date
28 Feb 2027
Ship
Queen Anne
- Departure - Valparaiso, Chile
- 11 stops
- Arrival - Fort Lauderdale, Florida
3 Available promotions:
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1 / 14
5 % off — 2 days left
Duration
16 nights
Date
2 Mar 2027
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
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1 / 17
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Duration
10 nights
Date
5 Mar 2027
Ship
Marina
- Departure - Miami, Florida, USA
- 10 stops
- Arrival - Panama City, Panama
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1 / 17
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Duration
20 nights
Date
5 Mar 2027
Ship
Marina
- Departure - Miami, Florida, USA
- 19 stops
- Arrival - Miami, Florida, USA
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1 / 9
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Duration
22 nights
Date
9 Mar 2027
Ship
Seven Seas Grandeur
- Departure - Panama City, Panama
- 10 stops
- Arrival - Panama City, Panama
1 / 14
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Duration
19 nights
Date
10 Mar 2027
Ship
Azamara Journey
- Departure - San Antonio, Chile
- 13 stops
- Arrival - Miami, Florida, USA
Available promotion:
up to $750 Onboard Credit
1 / 10
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Duration
16 nights
Date
10 Mar 2027
Ship
Seven Seas Mariner
- Departure - Callao (Lima), Peru
- 13 stops
- Arrival - Miami, Florida, USA
1 / 17
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Duration
10 nights
Date
15 Mar 2027
Ship
Marina
- Departure - Panama City, Panama
- 10 stops
- Arrival - Miami, Florida, USA
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1 / 14
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Duration
16 nights
Date
18 Mar 2027
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
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1 / 14
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Duration
11 nights
Date
18 Mar 2027
Ship
Azamara Journey
- Departure - Callao (Lima), Peru
- 7 stops
- Arrival - Miami, Florida, USA
Available promotion:
up to $750 Onboard Credit
1 / 26
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Duration
16 nights
Date
26 Mar 2027
Ship
Brilliant Lady
- Departure - Miami, Florida, USA
- 8 stops
- Arrival - Los Angeles, USA
Show all departures (2)
1 / 29
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Duration
29 nights
Date
28 Mar 2027
Ship
MSC Poesia
- Departure - Miami, Florida, USA
- 17 stops
- Arrival - Seattle, USA
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1 / 17
Duration
16 nights
Date
29 Mar 2027
Ship
Carnival Spirit
- Departure - Mobile (Alabama), USA
- 6 stops
- Arrival - Seattle, USA
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1 / 9
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Duration
14 nights
Date
31 Mar 2027
Ship
Seven Seas Grandeur
- Departure - Panama City, Panama
- 12 stops
- Arrival - Miami, Florida, USA
1 / 25
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Duration
16 nights
Date
3 Apr 2027
Ship
Star Princess
- Departure - Fort Lauderdale, Florida
- 7 stops
- Arrival - Los Angeles, USA
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1 / 14
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Duration
16 nights
Date
3 Apr 2027
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
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1 / 19
Duration
16 nights
Date
4 Apr 2027
Ship
Carnival Legend
- Departure - Tampa, FL USA
- 7 stops
- Arrival - Seattle, USA
1 / 20
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Duration
16 nights
Date
4 Apr 2027
Ship
Crown Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 29
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Duration
18 nights
Date
8 Apr 2027
Ship
MSC Poesia
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Seattle, USA
Available promotion:
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1 / 29
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Duration
22 nights
Date
9 Apr 2027
Ship
Norwegian Bliss
- Departure - New York, USA
- 13 stops
- Arrival - Seattle, USA
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1 / 29
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Duration
19 nights
Date
9 Apr 2027
Ship
Norwegian Bliss
- Departure - New York, USA
- 11 stops
- Arrival - San Francisco, USA
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1 / 17
Duration
15 nights
Date
18 Apr 2027
Ship
Celebrity Summit
- Departure - Tampa, FL USA
- 8 stops
- Arrival - Los Angeles, USA
1 / 14
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Duration
16 nights
Date
19 Apr 2027
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
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1 / 19
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Duration
15 nights
Date
21 Apr 2027
Ship
Norwegian Joy
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Los Angeles, USA
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1 / 14
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Duration
17 nights
Date
24 May 2027
Ship
Azamara Quest
- Departure - San Diego, USA
- 10 stops
- Arrival - Miami, Florida, USA
Available promotion:
up to $750 Onboard Credit
1 / 17
Duration
18 nights
Date
18 Sep 2027
Ship
Celebrity Summit
- Departure - Los Angeles, USA
- 8 stops
- Arrival - Boston, USA
1 / 14
5 % off — 2 days left
Duration
23 nights
Date
22 Sep 2027
Ship
Coral Princess
- Departure - Vancouver, Canada
- 11 stops
- Arrival - New York, USA
Available promotion:
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1 / 17
Duration
16 nights
Date
25 Sep 2027
Ship
Carnival Spirit
- Departure - Seattle, USA
- 6 stops
- Arrival - Galveston, Texas, USA
1 / 14
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Duration
18 nights
Date
27 Sep 2027
Ship
Coral Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - New York, USA
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1 / 29
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Duration
19 nights
Date
27 Sep 2027
Ship
MSC Poesia
- Departure - Seattle, USA
- 9 stops
- Arrival - Miami, Florida, USA
1 / 19
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Duration
17 nights
Date
30 Sep 2027
Ship
Norwegian Joy
- Departure - Los Angeles, USA
- 11 stops
- Arrival - Miami, Florida, USA
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1 / 25
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Duration
23 nights
Date
3 Oct 2027
Ship
Star Princess
- Departure - Vancouver, Canada
- 11 stops
- Arrival - Port Canaveral (Orlando), USA
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1 / 14
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Duration
23 nights
Date
6 Oct 2027
Ship
Island Princess
- Departure - Vancouver, Canada
- 13 stops
- Arrival - Fort Lauderdale, Florida
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1 / 15
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Duration
15 nights
Date
7 Oct 2027
Ship
Serenade of the Seas
- Departure - San Diego, USA
- 8 stops
- Arrival - Tampa, FL USA
Available promotion:
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1 / 25
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Duration
16 nights
Date
10 Oct 2027
Ship
Star Princess
- Departure - Los Angeles, USA
- 7 stops
- Arrival - Port Canaveral (Orlando), USA
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1 / 26
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Duration
32 nights
Date
10 Oct 2027
Ship
Vista
- Departure - Montreal, Canada
- 21 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 14
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Duration
16 nights
Date
13 Oct 2027
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
Available promotion:
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1 / 29
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Duration
17 nights
Date
19 Oct 2027
Ship
Norwegian Bliss
- Departure - Los Angeles, USA
- 11 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 29
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Duration
20 nights
Date
19 Oct 2027
Ship
Norwegian Bliss
- Departure - Los Angeles, USA
- 12 stops
- Arrival - New York, USA
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1 / 21
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Duration
16 nights
Date
24 Oct 2027
Ship
Emerald Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
Available promotion:
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1 / 26
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Duration
18 nights
Date
24 Oct 2027
Ship
Vista
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 9
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Duration
14 nights
Date
4 Nov 2027
Ship
Seven Seas Grandeur
- Departure - New York, USA
- 8 stops
- Arrival - Miami, Florida, USA
1 / 26
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Duration
17 nights
Date
27 Nov 2027
Ship
Brilliant Lady
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Miami, Florida, USA
1 / 13
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Duration
29 nights
Date
6 Dec 2027
Ship
Sonata
- Departure - Miami, Florida, USA
- 19 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 14
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Duration
16 nights
Date
13 Dec 2027
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 13
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Duration
16 nights
Date
19 Dec 2027
Ship
Sonata
- Departure - Miami, Florida, USA
- 10 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 9
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Duration
16 nights
Date
20 Dec 2027
Ship
Seven Seas Splendor
- Departure - Miami, Florida, USA
- 8 stops
- Arrival - San Francisco, USA
1 / 14
5 % off — 2 days left
Duration
28 nights
Date
27 Dec 2027
Ship
Azamara Quest
- Departure - Bridgetown, Barbados
- 21 stops
- Arrival - Valparaiso, Chile
Available promotion:
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1 / 14
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Duration
16 nights
Date
29 Dec 2027
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
Available promotion:
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1 / 14
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Duration
15 nights
Date
3 Jan 2028
Ship
Coral Princess
- Departure - Fort Lauderdale, Florida
- 8 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 14
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Duration
9 nights
Date
5 Jan 2028
Ship
Azamara Quest
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Panama City, Panama
Available promotion:
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1 / 17
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Duration
14 nights
Date
5 Jan 2028
Ship
Azamara Onward
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Callao (Lima), Peru
Available promotion:
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1 / 12
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Duration
14 nights
Date
5 Jan 2028
Ship
Sirena
- Departure - Miami, Florida, USA
- 11 stops
- Arrival - Callao (Lima), Peru
Available promotion:
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1 / 14
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Duration
19 nights
Date
5 Jan 2028
Ship
Azamara Quest
- Departure - Miami, Florida, USA
- 15 stops
- Arrival - Valparaiso, Chile
Available promotion:
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1 / 12
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Duration
65 nights
Date
5 Jan 2028
Ship
Sirena
- Departure - Miami, Florida, USA
- 40 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 17
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Duration
10 nights
Date
6 Jan 2028
Ship
Marina
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Panama City, Panama
Available promotion:
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1 / 17
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Duration
20 nights
Date
6 Jan 2028
Ship
Marina
- Departure - Miami, Florida, USA
- 16 stops
- Arrival - Miami, Florida, USA
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1 / 13
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Duration
16 nights
Date
6 Jan 2028
Ship
Sonata
- Departure - Los Angeles, USA
- 10 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 13
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Duration
44 nights
Date
6 Jan 2028
Ship
Sonata
- Departure - Los Angeles, USA
- 27 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 35
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Duration
15 nights
Date
9 Jan 2028
Ship
Norwegian Encore
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 35
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Duration
27 nights
Date
11 Jan 2028
Ship
Queen Anne
- Departure - Southampton, Great Britain
- 10 stops
- Arrival - Los Angeles, USA
3 Available promotions:
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1 / 10
5 % off — 2 days left
Duration
14 nights
Date
13 Jan 2028
Ship
Seven Seas Voyager
- Departure - Miami, Florida, USA
- 10 stops
- Arrival - Callao (Lima), Peru
1 / 14
5 % off — 2 days left
Duration
16 nights
Date
14 Jan 2028
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 17
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Duration
10 nights
Date
16 Jan 2028
Ship
Marina
- Departure - Panama City, Panama
- 8 stops
- Arrival - Miami, Florida, USA
Available promotion:
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1 / 35
5 % off — 2 days left
Duration
15 nights
Date
23 Jan 2028
Ship
Queen Anne
- Departure - Miami, Florida, USA
- 7 stops
- Arrival - Los Angeles, USA
3 Available promotions:
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1 / 35
5 % off — 2 days left
Duration
15 nights
Date
23 Jan 2028
Ship
Queen Anne
- Departure - Miami, Florida, USA
- 7 stops
- Arrival - Los Angeles, USA
3 Available promotions:
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1 / 35
Discount — 2 days left
Duration
15 nights
Date
24 Jan 2028
Ship
Norwegian Encore
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 14
5 % off — 2 days left
Duration
16 nights
Date
30 Jan 2028
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
Available promotion:
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1 / 14
5 % off — 2 days left
Duration
16 nights
Date
15 Feb 2028
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
Available promotion:
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1 / 14
5 % off — 2 days left
Duration
16 nights
Date
2 Mar 2028
Ship
Island Princess
- Departure - Los Angeles, USA
- 9 stops
- Arrival - Fort Lauderdale, Florida
Available promotion:
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1 / 17
5 % off — 2 days left
Duration
12 nights
Date
2 Mar 2028
Ship
Seven Seas Prestige
- Departure - Miami, Florida, USA
- 8 stops
- Arrival - Panama City, Panama
1 / 17
5 % off — 2 days left
Duration
10 nights
Date
5 Mar 2028
Ship
Marina
- Departure - Miami, Florida, USA
- 8 stops
- Arrival - Panama City, Panama
Available promotion:
Your World Included™ - Choice of Complimentary Wine & Beer or Shore Excursion Credit
1 / 17
5 % off — 2 days left
Duration
20 nights
Date
5 Mar 2028
Ship
Marina
- Departure - Miami, Florida, USA
- 15 stops
- Arrival - Miami, Florida, USA
Available promotion:
Your World Included™ - Choice of Complimentary Wine & Beer or Shore Excursion Credit
1 / 17
5 % off — 2 days left
Duration
12 nights
Date
14 Mar 2028
Ship
Seven Seas Prestige
- Departure - Panama City, Panama
- 8 stops
- Arrival - Miami, Florida, USA
1 / 17
5 % off — 2 days left
Duration
10 nights
Date
15 Mar 2028
Ship
Marina
- Departure - Panama City, Panama
- 8 stops
- Arrival - Miami, Florida, USA
Available promotion:
Your World Included™ - Choice of Complimentary Wine & Beer or Shore Excursion Credit
1 / 23
Duration
14 nights
Date
6 Apr 2028
Ship
Carnival Luminosa
- Departure - Los Angeles, USA
- 6 stops
- Arrival - Miami, Florida, USA
1 / 29
5 % off — 2 days left
Duration
18 nights
Date
6 Apr 2028
Ship
MSC Poesia
- Departure - Miami, Florida, USA
- 9 stops
- Arrival - Seattle, USA
1 / 25
5 % off — 2 days left
Duration
16 nights
Date
7 Apr 2028
Ship
Star Princess
- Departure - Port Canaveral (Orlando), USA
- 8 stops
- Arrival - Los Angeles, USA
Available promotion:
All-In: Upgrade to 'Princess Plus' for £58pp/pd
100 of 151 pcs